462 Murine intestinal commensal bacteria modulate the cutaneous inflammatory response to imiquimod
نویسندگان
چکیده
منابع مشابه
Dietary polyphenols can modulate the intestinal inflammatory response.
Inflammatory bowel diseases (IBD) arise from multiple causes, including environmental factors, gut microflora, immunity, and genetic predispositions. In the course of IBD, immune homeostasis and intestinal mucosa barrier integrity are impaired. Among natural preventive treatments that have been identified to date, polyphenols appear as promising candidates. They have been shown to protect again...
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M icrobes have a knack for making us sick. Until recently, many of these encounters proved deadly. In Guns, Germs, and Steel, evolutionary biologist Jared Diamond argues that such interactions were a primary force shaping human history. Therefore, it is not surprising that human-microbe interactions often are viewed through the lens of conflict. The proliferation of antibacterial consumer produ...
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In healthy subjects, the intestinal microbiota interacts with the host's epithelium, regulating gene expression to the benefit of both, host and microbiota. The underlying mechanisms remain poorly understood, however. Although many gut bacteria are not yet cultured, constantly growing culture collections have been established. We selected 57 representative commensal bacterial strains to study b...
متن کاملCommensal bacteria exacerbate intestinal inflammation but are not essential for the development of murine ileitis.
The pathogenesis of Crohn's disease has been associated with a dysregulated response of the mucosal immune system against intraluminal Ags of bacterial origin. In this study, we have investigated the effects of germfree (GF) conditions in the SAMP1/YitFc murine model of Crohn's disease-like ileitis. We show that the bacterial flora is not essential for ileitis induction, because GF SAMP1/YitFc ...
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Gut commensal bacteria play important roles in the development and homeostasis of intestinal immunity. However, the role of gut commensals in intestinal ischemia/reperfusion (I/R) injury is unclear. To determine the roles of gut commensal bacteria in intestinal IR injury, we depleted gut microbiota with a broad-spectrum antibiotic cocktail and performed mesenteric I/R (M I/R). First, we confirm...
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ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2016
ISSN: 0022-202X
DOI: 10.1016/j.jid.2016.02.498